Cannabinoids lead to enhanced virulence of the smallpox vaccine (vaccinia) virus
From a 2011 article published in the journal Immunobiology (https://www.journals.elsevier.com/immunobiology) researchers found that a single dose of cannabis resin was equally active as Δ9-tetrahydrocannabinol (THC) enhancing severity and duration of symptoms in vaccinia virus-infected mice. Cowpox virus did not cause symptomatic disease, but some reduction of specific antibody production was observed in drug-treated animals. In